The full answer
Rarely, but it's technically possible
Most toothpaste is gluten-free, but a small number of brands have used gluten-derived ingredients in the past. Since toothpaste isn’t swallowed in meaningful quantities, the risk is generally considered low even when it does contain trace gluten.
For extra peace of mind
If you want certainty, several toothpaste brands explicitly market themselves as gluten-free — checking the label or manufacturer’s website is the simplest way to confirm.
Important context
Individual symptoms, reactions, medical histories, food products, and local labeling rules can vary. Community experiences are not medical evidence.
For personal medical decisions, diagnosis, testing, or treatment, consult a qualified healthcare professional.