The full answer
Yes — patchy damage can be missed
Intestinal damage in celiac disease isn’t always evenly distributed, so if biopsy samples happen to come from a less-affected area, results can occasionally come back inconclusive or falsely normal, especially early in the disease process.
How doctors reduce this risk
To minimize this, doctors typically take multiple samples from different parts of the small intestine during one procedure. If a biopsy is negative but blood tests or symptoms strongly suggest celiac disease, further evaluation is usually warranted rather than closing the door on the diagnosis.
Important context
Individual symptoms, reactions, medical histories, food products, and local labeling rules can vary. Community experiences are not medical evidence.
For personal medical decisions, diagnosis, testing, or treatment, consult a qualified healthcare professional.